The Review of Diabetic Studies

The Association between Spexin Levels, Lipid Profiles, Glucose Metabolism, and Immune Function in Newly Diagnosed Diabetes in Postmenopausal Iraqi Women

Mustafa S. Shareef
1College of Health and Medical Techniques, AL-Bayan University, Baghdad, Iraq. 2Department of Biochemistry, Faculty of Medicine, University of Sousse, Tunisia.
Bassem Charfeddine
Department of Biochemistry, Faculty of Medicine, University of Sousse, Tunisia.
Ali B. Roomi
Department of Quality Assurance, University of Thi-Qar, Thi- Qar, 64001, Iraq.


Background: Type 2 diabetes mellitus (TIIDM) is a metabolic disorder in which the level of glucose is elevated in the blood as a consequence of insulin resistance. Spexin (SPX) is a peptide involved in the regulation of blood glucose and lipid metabolism. Aims: The study aims were targeting the pathophysiology of TIIDM in postmenopausal women (PMW), where it focused on the evaluation of SPX levels in the serum of TIIDM-PMW. Results: There was a significant (P<0.001) difference in waist circumference and waist-to--to-‎height ratio between TIIDM and non-diabetic PMW, which indicates more ‎central fat in patients. FSG, HbA1c, insulin, and HOMA-IR levels were elevated ‎significantly in TIIDM PMW, indicating poor glycemic control. SPX ‎and SOD levels were significantly reduced in TIIDM patients, while MDA, CRP, and IL-6 ‎levels were significantly increased, reflecting oxidative stress and ‎inflammation. The lipid profile was changed significantly in TIIDM PMW. ‎Moreover, the correlation in TIIDM PMW indicated a positive ‎association between SPX and MDA, SPX and age, CRP and IL-6, CRP and age, IL-6 and ‎FSG, SOD and insulin, and a negative association between SPX and waist-to-height ratio, ‎SPX and FSG, SPX and HOMA-IR, and MDA and insulin. At last, SPX has shown ‎excellent sensitivity in the prognosis of TIIDM in PMW. ‎Conclusion: SPX has been shown to play an important role in the pathophysiology of TIIDM in PMW. Targeting SPX may provide a novel technique to maintain good glycemic control in diabetic patients.

Type 2 Diabetes Mellitus, Lipid Profile, MDA, CRP, IL-6,.



Demosthenes Panagiotakos

Abbreviation Title

Rev Diabet Stud