The Review of Diabetic Studies

The Effects of Vitamin D Supplementation in Newly Diagnosed Type 1 Diabetes Patients: Systematic Review of Randomized Controlled Trials

Elina Gregoriou
Department of Life Sciences, European University Cyprus, Engomi, 1516 Nicosia-Cyprus
Ioannis Mamais
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Greece
Irene Tzanetakou
Department of Life Sciences, European University of Cyprus, Nicosia, Cyprus, Engomi, 1516 Nicosia-Cyprus
Giagkos Lavranos
Department of Health Sciences, European University Cyprus, Engomi, 1516 Nicosia-Cyprus
Stavri Chrysostomou
Department of Life Sciences, School of Science, European University Cyprus, Engomi, 1516 Nicosia-Cyprus


AIM: The aim of this study was to examine the effects of vitamin D supplementation in patients newly diagnosed with type 1 diabetes (T1D) assessed by insulin needs and changes in glycemic indices, as evidenced by randomized controlled trials (RCTs). METHODS: A total of 7 RCTs were retrieved from PubMed/Medline and EBSCO databases by MeSH term search, and were reviewed systematically. The RCTs included examined the effects of alphacalcidole (n = 2), cholecalciferol (n = 2), and calcitriol (n = 3) supplementation on changes in daily insulin dose (DID), fasting Cpeptide (FCP), stimulated C-peptide (SCP), and HbA1c. In total, 287 individuals, diagnosed with T1D within a period of 4 weeks to 1 year and aged between 5 to 38 years, were examined. RESULTS: Significant positive effects on DID, FCP, and SCP levels were observed after supplementation with alphacalcidole and cholecalciferol, whereas supplementation with calcitriol showed no effect. CONCLUSIONS: Vitamin D supplementation in the form of alphacalcidole and cholecalciferol appears to be beneficial in the treatment of T1D patients by attenuating the natural history of the disease.

type 1 diabetes · new-onset diabetes · vitamin D · randomized control trial · insulin · HbA1c · pancreatic betacell · stimulated C-peptide · fasting C-peptide,.



Demosthenes Panagiotakos

Abbreviation Title

Rev Diabet Stud