Causes and Characteristics of Diabetic Cardiomyopathy

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The Review of Diabetic Studies,2006,3,3,108-117.
Published:November 2006
Type:Review Article
Author(s) affiliations:

Jianxun Wang1, Ye Song 2, Qianwen Wang 3, Patricia M. Kralik 2, Paul N. Epstein2

1Departments of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.

2Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.

3Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40202, USA.


Type 1 and type 2 diabetic patients are at increased risk of cardiomyopathy and heart failure is a major cause of death for these patients. Cardiomyopathy in diabetes is associated with a cluster of features including decreased diastolic compliance, interstitial fibrosis and myocyte hypertrophy. The mechanisms leading to diabetic cardiomyopathy remain uncertain. Diabetes is associated with most known risk factors for cardiac failure seen in the overall population, including obesity, dyslipidemia, thrombosis, infarction, hypertension, activation of multiple hormone and cytokine systems, autonomic neuropathy, endothelial dysfunction and coronary artery disease. In light of these common contributing pathologies it remains uncertain whether diabetic cardiomyopathy is a distinct disease. It is also uncertain which factors are most important to the overall incidence of heart failure in diabetic patients. This review focuses on factors that can have direct effects on diabetic cardiomyocytes: hyperglycemia, altered fuel use, and changes in the activity of insulin and angiotensin. Particular attention is given to the changes these factors can have on cardiac mitochondria and the role of reactive oxygen species in mediating injury to cardiomyocytes.