Article ViewAbstractThe Review of Diabetic Studies,2008,5,1,25-27.DOI:10.1900/RDS.2007.5.25Published:May 2008Type:Short ReportAuthors:Henning Gohlke, Uta Ferrari, Kerstin Koczwara, Ezio Bonifacio, Thomas Illig, and Anette-G Ziegler Author(s) affiliations:Henning Gohlke1, Uta Ferrari2, Kerstin Koczwara2, Ezio Bonifacio2, Thomas Illig1 and Anette-G. Ziegler2 1Institute of Epidemiology, Helmholtz Zentrum, Neuherberg, Germany. 2Diabetes Research Institute, Munich, Germany. Abstract:(zinc transporter 8, ZnT8) single nucleotide polymorphism (SNP) rs13266634 was associated with type 2 diabetes and with reduced insulin secretion in non-diabetic relatives. Because of its role in beta-cell function, we hypothesized that this candidate SNP may confer increased susceptibility for beta-cell destruction in type 1 diabetes. We analyzed SLC30A8 genotypes in 874 patients with type 1 diabetes and 1021 control subjects. No difference in allele and genotype frequencies of the SLC30A8 SNP rs13266634 was found between patients and controls. Analysis with respect to age at type 1 diabetes onset, however, showed that patients with a diabetes onset before age 5 years had an increased prevalence of the cytosine (C) allele (risk allele, 82%) and the homozygous CC genotype (65%) compared to patients who developed type 1 diabetes after age 5 years (67% and 49%; p < 0.01) and compared to controls (69% and 48%; p < 0.03). These data suggest that genetic susceptibility for beta-cell dysfunction in the presence of autoimmunity may lead to accelerated progression and early manifestation of the disease. Keywords:Age of onset, Beta-cell dysfunction, Genotype, SCL30A8, Type 1 diabetes, Zinc transporter, ZnT-8View:PDF (256.04 KB) PDFClick here to download the PDF file. Images Association of SLC30A8 SNP rs13266634 with age at type 1 diabetes onset in 874 type 1 diabetic patients ‹ The Role of Skeletal Muscle Sphingolipids in the Development of Insulin Resistance up Adiponectin and Adiponectin Receptor Gene Variants in Relation to Type 2 Diabetes and Insulin Resistance-Related Phenotypes ›