Article ViewAbstractThe Review of Diabetic Studies,2009,6,2,85-96.DOI:10.1900/RDS.2009.6.85Published:August 2009Type:Review Article Authors:Ken T Coppieters, and Matthias G von Herrath Author(s) affiliations:Ken T. Coppieters and Matthias G. von Herrath La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Abstract:Although our knowledge on the various aspects of diabetes development in the NOD mouse model is substantial and keeps expanding at a dramatic pace, the dataset on histopathologic features of type 1 diabetes (T1D) in patients remains largely stagnant. Early work has established an array of common aspects that have become epitomic in the absence of new patient material. There is a growing consensus that an updated and more detailed view is required that challenges and expands our understanding. Comprehensive initiatives are currently ongoing to address these issues in prediabetic, recent onset and longstanding type 1 diabetic individuals, and some of the old data have been recently revisited. In this review article, we wish to provide an overview of where we stand today and how we can correlate the various cross-sectional studies from the past with contemporary models of the disease. We believe an enhanced understanding of the many histopathological particularities in patients as compared to animal models will ultimately lead, not only to more fundamental insights, but also to an improved ability to translate pre-clinical data from bench to bedside. Keywords:Apoptosis, Autoantibody, Beta-cell, Cytotoxic T lymphocyte, Inflammation, Insulitis, Pancreas, Replication, Type 1 diabetes, VirusView:PDF (2.91 MB) PDFClick here to download the PDF file. Images Local early events in islets leading to β-cell death ‹ The Role of the CXCL10/CXCR3 System in Type 1 Diabetes up Allelic Variation of Ets1 Does Not Contribute to NK and NKT Cell Deficiencies in Type 1 Diabetes Susceptible NOD Mice ›