Gender-Specific Differences in the Association of Adiponectin Gene Polymorphisms with Body Mass Index

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The Review of Diabetic Studies,2010,7,3,241-246.
Published:November 2010
Type:Original Article
Author(s) affiliations:

Ozra Tabatabaei-Malazy1, Shirin Hasani-Ranjbar1, Mahsa M. Amoli1, Ramin Heshmat1, Mohammadali Sajadi2, Reza Derakhshan2, Parvin Amiri1, Mahsa Namakchian1, Ebrahim Rezazadeh2, Javad Tavakkoly-Bazzaz1,3, Abbasali Keshtkar1,4, and Bagher Larijani1

1Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.

2Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

3Division Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

4Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.


Objective: Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D). The study evaluated possible associations of +45T/G and -11391G/A adiponectin gene polymorphisms with body mass index (BMI), waist circumferences (WC), and blood pressure in diabetic and non-diabetic Iranians. Methods: This cross-sectional study involved two groups of subjects: 243 diabetic patients and 173 non-diabetic subjects recruited from Rafsanjan city in the south-east of Iran. Results: No significant association was found between +45T/G and - 11391G/A adiponectin gene polymorphisms and systolic or diastolic blood pressure. However, male carriers of the TT genotype of +45T/G had a significantly higher mean BMI than male GG homozygotes (p = 0.018). Also, male carriers of the GG genotype of -11391G/A had significantly higher mean BMI than male GA or AA homozygotes (p = 0.041). Female carriers of the GG genotype of -11391G/A had significantly higher mean WC than female GA or AA homozygotes (p = 0.038). Conclusion: We observed a significantly higher BMI in women, and GA or AA carriers of - 11391G/A polymorphism. Also, there was a significantly lower WC in females and GG carriers of +45T/G. These results point to a gender-specific impact of the studied genotypes on BMI and WC.