The Effects of Vitamin D Supplementation in Newly Diagnosed Type 1 Diabetes Patients: Systematic Review of Randomized Controlled Trials

Authors

  • Elina Gregoriou Department of Life Sciences, European University Cyprus, Engomi, 1516 Nicosia-Cyprus
  • Ioannis Mamais Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Greece
  • Irene Tzanetakou Department of Life Sciences, European University of Cyprus, Nicosia, Cyprus, Engomi, 1516 Nicosia-Cyprus
  • Giagkos Lavranos Department of Health Sciences, European University Cyprus, Engomi, 1516 Nicosia-Cyprus
  • Stavri Chrysostomou Department of Life Sciences, School of Science, European University Cyprus, Engomi, 1516 Nicosia-Cyprus

Keywords:

type 1 diabetes · new-onset diabetes · vitamin D · randomized control trial · insulin · HbA1c · pancreatic betacell · stimulated C-peptide · fasting C-peptide

Abstract

AIM: The aim of this study was to examine the effects of vitamin D supplementation in patients newly diagnosed with type 1 diabetes (T1D) assessed by insulin needs and changes in glycemic indices, as evidenced by randomized controlled trials (RCTs). METHODS: A total of 7 RCTs were retrieved from PubMed/Medline and EBSCO databases by MeSH term search, and were reviewed systematically. The RCTs included examined the effects of alphacalcidole (n = 2), cholecalciferol (n = 2), and calcitriol (n = 3) supplementation on changes in daily insulin dose (DID), fasting Cpeptide (FCP), stimulated C-peptide (SCP), and HbA1c. In total, 287 individuals, diagnosed with T1D within a period of 4 weeks to 1 year and aged between 5 to 38 years, were examined. RESULTS: Significant positive effects on DID, FCP, and SCP levels were observed after supplementation with alphacalcidole and cholecalciferol, whereas supplementation with calcitriol showed no effect. CONCLUSIONS: Vitamin D supplementation in the form of alphacalcidole and cholecalciferol appears to be beneficial in the treatment of T1D patients by attenuating the natural history of the disease.

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Published

2017-08-14

Issue

Vol. 14 No. 2-3 (2017): Volume 14 issue 2-3 2017

Section

Articles