Evaluation Of Mineralized Plasmatic Matrix Prepared From Xenogeneic Bone In Mandibular Defects Grafting After Cystectomy In Diabetic Patient: A Prospective Randomized Clinical Trial

Abstract

Objective: To evaluate the usage of Mineralized Plasmatic Matrix prepared from Xenogeneic Bone (MPM-XB) in the healing process of mandibular defects after cystectomy in diabetic patients by using density measuring and volumetric analysis with cone beam computed tomography (CBCT).

Patients and Methods: This study involved 12 diabetic cases with cystic lesions of the mandible. MPM-XB is used to fill the cavity after cystectomy. At the post-operative 3^rd and 6^th months, the implanted bone was evaluated by matching the CBCT scan in terms of density and volume compared with the mandibular cystic lesion volume.

Results: Bone density significantly increased from 378.7 ± 67.5 in the third month to 398.4 ± 73.1 in the sixth month  (p = 0.011), while volumetric analysis showed a non-significant difference between preoperative and 6 months after, regarding cystic volume and graft volume as well as the ratio between both (P > 0.05).

Conclusion: Mineralized plasmatic matrix prepared from xenogeneic bone appeared to be stable with appropriate bone density and minimal complications in filling bone defects after cystectomy in diabetic patients with mandibular cystic lesions.