The Review of Diabetic Studies

Diabetic Kidney Disease: A Syndrome Rather Than a Single Disease

Giorgina B. Piccoli , Marta Nazha, Simona Roggero, Irene Capizzi , Cristina Di Vico
SS Nefrologia, SCDU Urologia, San Luigi Gonzaga Hospital, Department of Clinical and Biological Sciences, University of Torino, Italy
Giorgio Grassi
SCDU Endocrinologia, Diabetologia e Metabolismo, Citta della Salute e della Scienza Torino, Italy
Gianfranca Cabiddu, Stefania Maxia, Valentina Loi, Antonello Pani
SC Nefrologia, Brotzu Hospital, Cagliari, Italy
Agostino De Pascale, Adriano M. Priola, Andrea Veltri
SCDU Radiologia, san Luigi Gonzaga Hospital, Department of Oncology, University of Torino, Italy
Anna M. Asunis
SCD Anatomia Patologica, Brotzu Hospital, Cagliari, Italy


The term “diabetic kidney” has recently been proposed to encompass the various lesions, involving all kidney structures that characterize protean kidney damage in patients with diabetes. While glomerular diseases may follow the stepwise progression that was described several decades ago, the tenet that proteinuria identifies diabetic nephropathy is disputed today and should be limited to glomerular lesions. Improvements in glycemic control may have contributed to a decrease in the prevalence of glomerular lesions, initially described as hallmarks of diabetic nephropathy, and revealed other types of renal damage, mainly related to vasculature and interstitium, and these types usually present with little or no proteinuria. Whilst glomerular damage is the hallmark of microvascular lesions, ischemic nephropathies, renal infarction, and cholesterol emboli syndrome are the result of macrovascular involvement, and the presence of underlying renal damage sets the stage for acute infections and drug-induced kidney injuries. Impairment of the phagocytic response can cause severe and unusual forms of acute and chronic pyelonephritis. It is thus concluded that screening for albuminuria, which is useful for detecting “glomerular diabetic nephropathy”, does not identify all potential nephropathies in diabetes patients. As diabetes is a risk factor for all forms of kidney disease, diagnosis in diabetic patients should include the same combination of biochemical, clinical, and imaging tests as employed in nondiabetic subjects, but with the specific consideration that chronic kidney disease (CKD) may develop more rapidly and severely in diabetic patients.

diabetes · chronic kidney disease · diabetic nephropathy · glomerulosclerosis · glomeruli · retinopathy,.



Demosthenes Panagiotakos

Abbreviation Title

Rev Diabet Stud