The Review of Diabetic Studies

Association Between Low-Grade Systemic Inflammation and Type 2 Diabetes Mellitus Among Men and Women from the ATTICA Study

Christos Pitsavos , Yannis Skoumas , Christina Chrysohoou, Christodoulos Stefanadis
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
Metaxia Tampourlou, Demosthenes B. Panagiotakos, Tzortzis Nomikos
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.


AIM: The aim is to investigate the relationship between lowgrade inflammation and several glycemic indices in a population-based sample of men and women. METHODS: The ATTICA study is a population-based cohort that randomly enrolled 1514 men and 1528 women (aged >18 years old), stratified by age and gender, from the Greater Athens area, during 2001-2002. Among several characteristics, inflammation markers (high sensitivity C-reactive protein, interleukin6, tumor necrosis factor-alpha, homocysteine and amyloid A) and glycemic control indices (fasting blood glucose, insulin, HOMA) were measured in the participants. RESULTS: The prevalence of diabetes was 7.8% in men and 6.0% in women. The prevalence of impaired fasting glucose (IFG) was 21% in men and 12% in women. Diabetic subjects had 57% higher mean levels of C-reactive protein (p < 0.001), 22% higher mean levels of interleukin-6 (p < 0.001) and 60% higher levels of tumor necrosis factor-alpha (p < 0.001) compared to non-diabetic subjects. Homocysteine and serum amyloid A levels did not show significant differences among groups. CONCLUSION: Our study supports a positive association between low-grade inflammation and diabetes in a population-based sample of men and women without any evidence of cardiovascular disease, which is independent of demographic, clinical and lifestyle characteristics, including physical activity and dietary factors.

type 2 diabetes · C-reactive protein · interleukin-6 · TNF-alpha · glycemic control,.



Demosthenes Panagiotakos

Abbreviation Title

Rev Diabet Stud